The Role of Spatial Ability in Learning with Virtual Reality: A Literature Review

No research has systematically reviewed the role of spatial ability in virtual reality (VR) learning. This has resulted in inefficiencies in educators’ ability to adopt personalized teaching strategies based on learners’ spatial ability to maximize the effectiveness of VR. Therefore, this study conducted a literature review on spatial ability in VR learning to provide researchers and educators with a comprehensive understanding of how spatial ability affects VR learning. After searching Scopus with keywords and applying inclusion and exclusion criteria, the researchers identified 30 relevant research articles for the review. This literature review mainly analyzed research trends, contexts, theories, methodologies, and findings from the identified articles. The contradictory role of spatial ability in VR learning was also summarized. Based on the literature analysis, this study identified research gaps and indicated directions for future research

CKNet: A Convolutional Neural Network Based on Koopman Operator for Modeling Latent Dynamics from Pixels

With the development of end-to-end control based on deep learning, it is important to study new system modeling techniques to realize dynamics modeling with high-dimensional inputs. In this paper, a novel Koopman-based deep convolutional network, called CKNet, is proposed to identify latent dynamics from raw pixels. CKNet learns an encoder and decoder to play the role of the Koopman eigenfunctions and modes, respectively. The Koopman eigenvalues can be approximated by eigenvalues of the learned state transition matrix. The deterministic convolutional Koopman network (DCKNet) and the variational convolutional Koopman network (VCKNet) are proposed to span some subspace for approximating the Koopman operator respectively. Because CKNet is trained under the constraints of the Koopman theory, the identified latent dynamics is in a linear form and has good interpretability. Besides, the state transition and control matrices are trained as trainable tensors so that the identified dynamics is also time-invariant. We also design an auxiliary weight term for reducing multi-step linearity and prediction losses. Experiments were conducted on two offline trained and four online trained nonlinear forced dynamical systems with continuous action spaces in Gym and Mujoco environment respectively, and the results show that identified dynamics are adequate for approximating the latent dynamics and generating clear images. Especially for offline trained cases, this work confirms CKNet from a novel perspective that we visualize the evolutionary processes of the latent states and the Koopman eigenfunctions with DCKNet and VCKNet separately to each task based on the same episode and results demonstrate that different approaches learn similar features in shapes.Comment: 8 pages, 7 figure

One Possible Mechanism of Pulsed Dye Laser Treatment on Infantile Hemangioma: Induction of Endothelial Apoptosis and Serum vascular endothelial growth factor (VEGF) Level Changes

Introduction: Pulsed dye laser (PDL) is an important treatment for superficial infantile hemangioma, but few studies report on its cellular mechanism. The aim of this study was to evaluate alterations of serum vascular endothelial growth factor (VEGF) level in infantile hemangioma (IH) patients after laser treatment and effects of PDL irradiation on human umbilical vein endothelial cells (HUVECs) in vitro, as well as to explore the biomolecular mechanisms and ultrastructure changes of the PDL effect.Methods: 74 children with infant hemangioma including 45 patients in proliferating phase, 18 patients in involuting phase, 11 patients in involuted phase and 10 healthy children were engaged in this study. The plasma VEGF levels of children were measured with the enzyme-linked immunosorbent assay (ELISA). 24 hours after, HUVECs cultured in vitro were irradiated with PDL, cell apoptosis, mRNA levels of VEGF, and changes of ultrastructure were evaluated using flow cytometry, real-time reverse transcriptase polymerase chain reaction (RT-PCR), and transmission electron microscopy, respectively.Results: The serum VEGF concentrations in children with proliferating hemangiomas were significantly higher than in patients with involuting / involved hemangiomas and healthy patients. After receiving 3 laser treatments, the plasma VEGF levels of IH patients in proliferating hemangiomas decreased significantly. PDL irradiation could down-regulate VEGF mRNA expression of HUVECs, and increase cell apoptosis rate. Conclusion: The present study demonstrates that PDL irradiation imparts apoptosis induction effects on HUVECs in vitro. Furthermore, our results suggest that vascular endothelial growth factor may be of particular importance in pathophysiology and PDL treatment of hemangiomas, also serum VEGF levels may be used as an aid in the follow up of IH. This provides valuable evidence of the PDL effect on infantile hemangioma

The concentrations of bone calcium, phosphorus and trace metal elements in elderly patients with intertrochanteric hip fractures

IntroductionTrace metal elements may play a crucial role in bone mineralization and metabolism. However, the quantification of trace element concentrations in human bone tissue has received little attention.Materials and methodsBone tissue samples were collected from 55 elderly patients (15 males and 40 females) with intertrochanteric hip fractures. The calcium, phosphorus, manganese, iron, copper, and zinc concentrations in the cortical bone zone, cancellous bone zone, and junction zone between cortical and cancellous bone were determined by energy-dispersive X-ray fluorescence (EDX). The differences in trace element concentrations in the three regions were compared, and the correlation between gender and bone trace element contents of the bones was analyzed using the Kruskal-Wallis’s test. The correlation between age, body mass index (BMI), and bone calcium, phosphorus concentrations, and trace elements in three bone zones was determined using Spearman correlation analysis.ResultsThe Kruskal-Wallis test showed no difference in bone phosphorus concentration among the three regions. In contrast, the difference in the concentrations of bone calcium and four metal elements was statistically significant (P<0.01). In addition, no statistical differences were observed in the concentrations of trace elements among the three regions in elderly male and female patients. Spearman correlation analysis showed a strong negative correlation between bone calcium and phosphorus in three bone regions (r=-0.999, -0.95, -0.998, P < 0.01) and a significant positive correlation between trace metal elements in the cancellous bone zone. In the junction zone, the BMI showed a strong positive correlation with bone calcium content (r=0.347, P=0.009) and a significant negative correlation with phosphorus content (r=-0.349, P=0.009).ConclusionBone calcium and phosphorus were the main components of hydroxyapatite, and these two elements accounted for the majority of bone mineral salts. Trace metal elements are essential for bone metabolism and specific synergistic interactions. BMI may be associated with bone calcium and phosphorus contents in elderly patients with osteoporosis

The multi-targeted kinase inhibitor sunitinib induces apoptosis in colon cancer cells via PUMA

Constitutive activation of pro-survival kinases has become a promising target of small molecules with an increasing interest in developing multi-targeted agents. The mechanisms underlying the responsiveness to most agents targeting cancer specific survival pathways are still poorly understood but critical for their clinical application. In this study, we found that sunitinib, a small molecule inhibitor of multiple tyrosine kinases including VEGFRs and PDGFRs induces apoptosis and inhibits cell growth in colon cancer cells in cell culture and xenograft models via the BH3-only protein PUMA. Sunitinib treatment induced PUMA transcription via the AKT/FoxO3a axis. PUMA, BH3 mimetics, or 5-Flurourical sensitized colon cancer cells to sunitinib-induced apoptosis. Furthermore, PUMA was induced by sunitinib treatment in xenograft tumors, and deficiency in PUMA significantly suppressed the anti-tumor effects of sunitinib. Our study suggests that PUMA-mediated apoptosis is important for the therapeutic responses to sunitinib, and activation of the mitochondrial pathway by BH3 mimetics or PUMA manipulation may be useful for improving the antitumor activity of sunitinib. Modulation of PUMA and selective Bcl-2 family members might be potential biomarkers for predicting sunitinib responses. © 2012 Sun et al

Robust Multimodal Failure Detection for Microservice Systems

Proactive failure detection of instances is vitally essential to microservice systems because an instance failure can propagate to the whole system and degrade the system's performance. Over the years, many single-modal (i.e., metrics, logs, or traces) data-based nomaly detection methods have been proposed. However, they tend to miss a large number of failures and generate numerous false alarms because they ignore the correlation of multimodal data. In this work, we propose AnoFusion, an unsupervised failure detection approach, to proactively detect instance failures through multimodal data for microservice systems. It applies a Graph Transformer Network (GTN) to learn the correlation of the heterogeneous multimodal data and integrates a Graph Attention Network (GAT) with Gated Recurrent Unit (GRU) to address the challenges introduced by dynamically changing multimodal data. We evaluate the performance of AnoFusion through two datasets, demonstrating that it achieves the F1-score of 0.857 and 0.922, respectively, outperforming the state-of-the-art failure detection approaches

Association of multiple blood metals with thyroid function in general adults: A cross−sectional study

IntroductionThyroid function has a large impact on humans’ metabolism and is affected by iodine levels, but there is a scarcity of studies that elucidate the association between thyroid function and other elements.MethodsWe performed a cross-sectional study on 1,067 adults to evaluate the associations of the common essential metals with thyroid function in adults living in an iodine-adequate area of China. Serum free thyroxine (FT4), free triiodothyronine (FT3), thyroid stimulating hormone (TSH), and blood metals (zinc, iron, copper, magnesium, manganese, and calcium) were measured. Further, the thyroid hormone sensitivity indexes, FT3:FT4 ratio, and thyrotropin T4 resistance index (TT4RI) were calculated. Linear regression, quantile g-computation, and Bayesian kernel machine regression methods were used to explore the association of metals with thyroid function.ResultsWe found that the TSH levels correlated with copper (negative) and zinc (positive). Iron and copper were positively associated with FT3 and FT4 levels, respectively. Iron (positive) and copper (negative) were correlated with the FT3:FT4 ratio. Furthermore, we found that manganese was inversely correlated with TT4RI, while zinc was positively correlated.DiscussionOur findings suggest that manganese, iron, copper, and zinc levels were strongly correlated with thyroid function, and patients with thyroid disorders are recommended to measure those metals levels

The Study on Newly Developed McAb NJ001 Specific to Non-Small Cell Lung Cancer and Its Biological Characteristics

Monoclonal antibody (McAb) is the key tool for cancer immunodiagnosis and immunotherapy. McAb-based immunotherapy that targets tumor antigens has had great achivement. In this study, a cell clone which kept secreting high-titer IgG1-type McAb named NJ001 against human non-small cell lung cancer (NSCLC) cells was obtained. The titer of purified NJ001 was 2×106. The antigen named SP70 of NSCLC specifically identified by NJ001 was proved to be a protein with the relative molecular mass (Mr) of 70 kDa. The results of immunohistochemical staining indicated that NJ001 could positively react to NSCLC, but weak positively or negatively react to human small-cell lung cancer (SCLC), pulmonary pseudotumor and other epithelial tumors. In soft agar assay, the colony formation efficiency in NJ001 groups decreased in a dose-dependent manner. For the concentration of 100 µg/ml, 200 µg/ml and 400 µg/ml, the inhibition ratio of colony formation was 23.4%, 62.5% and 100% respectively. Meanwhile, NJ001 caused significant reduction in tumor volume and tumor weight compared to control mice in lung cancer xenograft model. The tumor growth inhibition ratio in 200 µg, 400 µg and 800 µg NJ001 groups was 10.44%, 37.29% and 44.04%, respectively. NJ001 also led to cytomorphological changes and induced the apoptosis of human lung adenocarcinoma cell line SPC-A1 significantly. The newly developed NJ001 selectively reacted to NSCLC and exhibited anti-tumor activity both in vitro and in vivo. NJ001 is of great value concerning immunodiagnostics and immunotherapy for NSCLC and holds promise for further research regarding the mechanism underlying tumor progression of NSCLC

Seismic behavior of bridge pier column lap splices

Inadequate flexural strength and ductility, or shear strength, of concrete bridge columns have resulted in collapse or severe damage of a number of California bridges in recent moderate earth-quakes. In general, these bridges were designed prior to the new seismic design methods which were implemented in the mid-seventies. Bridges constructed in accordance with the new design methods have performed well in recent earthquakes. However, the large number of older bridges that are still in service, particularly freeway overpasses designed and constructed in the 1950's to 1970's, are now recognized to have substandard design details and to constitute a cause for major concern.The principal objective of this study is to provide basic knowledge on the performance of circular columns with noncontact lap splices at their maximum moment sections. As part of that work the validity of existing equations, (Darwin et al, 1995), for calculating the maximum bar stress (or bond strength of lap splice) at failure along the splice length is examined. Then a simple model is used to provide reasonable predictions of the response to seismic loadings of bridge columns with inadequate length lap splices at the column to foundation connection.This study involved both field and laboratory investigations. The field work involved the reversed cyclic lateral load testing to failure of four as--built large diameter circular columns which formed parts of existing bridge piers. However, due to the wide irregularities in the details of the field columns, it was not possible to determine the relative importance of the various parameters. Therefore, a laboratory investigation to examine physically what effects concrete cover, bar spacing and bar lap separation had on the behavior of columns with splices at the maximum moment region at their bases was undertaken in the Newmark Civil Engineering Laboratory.U of I OnlyETDs are only available to UIUC Users without author permissio